The booklet covers the difficult concept of how haemoglobin transports oxygen around the body and how the haemoglobin undergoes configurational change so that it bonds oxygen more easily after the first oxygen has joined. The booklet then introduces Oxygen dissociation curves why they are sigmoid shape and how they are made including what the partial pressures means in terms of tissues in the body. There are various amount of tasks in the booklet students are challenged to make a dissociation curve with some data and need to answer some key questions on what is happening at different parts of the graph in relation to partial pressure and haemoglobin shape. The booklet then compares haemoglobin with both myglobin the oxygen storage molecule found in muscles and foetal haemoglobin. Both have questions on what these molecules do and where they are situated on the oxygen dissociation curve graph in relation to adult haemoglobin. The booklet then introduces carbon dioxide transport in great detail and the three main methods it is transported in the blood. The booklet then finishes on the Bohr effect and how carbon dioxide affects the oxygen dissociation curve and what happens when different carbon dioxide concentrations affect haemogobin loading and unloading.

This resource has everything needed to teach and learn about the heart at OCR A level. The booklet starts at the basic structure of the heart and the main structures of heart anatomy both internal and external. The Structure is explained using a simple gap fill activity to allow students to learn and complete the first page of the booklet. The next is labeling the external and internal structures to allow students to orientate themselves. The next part of the booklet explains the key stages in the cardiac cycle using a simple gap fill and then goes on to explain the cardiac cycle graph with clear labels of what is happening the pressure changes in the atria and ventricles. The next part of the booklet explains the initiation of the cardiac cycle how the cardiac cells are myogenic and how the natural pacemaker SAN node triggers a wave of excitation over the atria and how the AVN node triggers ventricular contraction. The last part of the booklet explains ECG graphs and what each part does and how to recognise abnormal ECG traces.

Having learned about this in my Biochemistry degree. It has now been included in the OCR A level Biology A H420 Syllabus as a kind of introduction into cellular control. Having taught this for several years I have had to make my own resource as there is very little material out on it that is relevant to A level students and the textbooks don’t explain the Biochemistry fully. The resource is a Booklet gap fill with diagrams and the teacher telling them all about the various different mechanisms that control gene expression in organisms. It covers -Gene regulation-Transcriptional control : chromatin remodelling/Histone modification / Lac operon/cAMP-Post-Transcriptional control: RNA Processing /RNA editing-Translational control : protein kinases/inhibitory proteins/inititaion factors-Post-Translational control : phosphates/amino acid modification/folding proteins/cAMP modification

This power-point can go with the Booklet or on its own. It covers a whole lesson on the mechanisms that control gene expression in eukaryotes and prokaryotes. These include Transcription control e.g Chromatin remodelling and histone modifcation Post -transcriptional control e.g RNA processing and editing Translational control e.g Inhibitory proteins and initiation factors Post -translational control e.g phosphate groups and protein shortening